FT INIT_MET 1 1 Removed. FT CHAIN 2 269 Aquaporin-1. FT /FTId=PRO_0000063920. FT TOPO_DOM 2 7 Cytoplasmic. FT TRANSMEM 8 36 Helix 1. FT TOPO_DOM 37 48 Extracellular. FT TRANSMEM 49 66 Helix 2. FT TOPO_DOM 67 70 Cytoplasmic. FT TOPO_DOM 71 76 In membrane. FT TRANSMEM 77 84 Helix B. FT TOPO_DOM 85 94 Cytoplasmic. FT TRANSMEM 95 115 Helix 3. FT TOPO_DOM 116 136 Extracellular. FT TRANSMEM 137 155 Helix 4. FT TOPO_DOM 156 166 Cytoplasmic. FT TRANSMEM 167 183 Helix 5. FT TOPO_DOM 184 186 Extracellular. FT TOPO_DOM 187 192 In membrane. FT TRANSMEM 193 200 Helix E. FT TOPO_DOM 201 207 Extracellular. FT TRANSMEM 208 228 Helix 6. FT TOPO_DOM 229 269 Cytoplasmic. FT MOTIF 76 78 NPA 1. FT MOTIF 192 194 NPA 2. FT COMPBIAS 159 162 Poly-Arg. FT SITE 56 56 Substrate discrimination. FT SITE 180 180 Substrate discrimination. FT SITE 189 189 Hg(2+)-sensitive residue. FT SITE 195 195 Substrate discrimination. FT MOD_RES 246 246 Phosphothreonine (By similarity). FT MOD_RES 247 247 Phosphoserine (By similarity). FT MOD_RES 262 262 Phosphoserine. FT CARBOHYD 42 42 N-linked (GlcNAc...). FT CARBOHYD 205 205 N-linked (GlcNAc...) (Potential). FT VARIANT 38 38 P -> L (in Co(A-B-) antigen; non FT functional AQP1; red cells show low FT osmotic water permeability). FT /FTId=VAR_013279. FT VARIANT 45 45 A -> V (in Co(A-B+) antigen; FT dbSNP:rs28362692). FT /FTId=VAR_004400. FT VARIANT 165 165 G -> D (in dbSNP:rs28362731). FT /FTId=VAR_022318. FT CONFLICT 45 45 A -> T (in Ref. 7; AAH22486). FT HELIX 8 35 FT STRAND 37 42 FT HELIX 48 65 FT STRAND 68 71 FT HELIX 76 83 FT HELIX 94 114 FT TURN 119 122 FT STRAND 132 135 FT HELIX 136 154 FT HELIX 166 182 FT TURN 183 185 FT HELIX 192 199 FT HELIX 207 227