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ftreedistpair |
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These distances are computed by considering all possible branches that could exist on the the two trees. Each branch divides the set of species into two groups -- the ones connected to one end of the branch and the ones connected to the other. This makes a partition of the full set of species. (in Newick notation)
((A,C),(D,(B,E)))
has two internal branches. One induces the partition {A, C | B, D, E} and the other induces the partition {A, C, D | B, E}. A different tree with the same set of species,
(((A,D),C),(B,E))
has internal branches that correspond to the two partitions {A, C, D | B, E} and {A, D | B, C, E}. Note that the other branches, all of which are external branches, induce partitions that separate one species from all the others. Thus there are 5 partitions like this: {C | A, B, D, E} on each of these trees. These are always present on all trees, provided that each tree has each species at the end of its own branch.
In the case of the Branch Score distance, each partition that does exist on a tree also has a branch length associated with it. Thus if the tree is
(((A:0.1,D:0.25):0.05,C:0.01):0.2,(B:0.3,E:0.8):0.2)
The list of partitions and their branch lengths is:
{A | B, C, D, E} 0.1
{D | A, B, C, E} 0.25
{A, D | B, C, E} 0.05
{C | A, B, D, E} 0.01
{A, D, C | B, E} 0.4
{B | A, C, D, E} 0.3
{E | A, B, C, D} 0.8
Note that the tree is being treated as unrooted here, so that the branch lengths on either side of the rootmost node are summed up to get a branch length of 0.4.
The Branch Score Distance imagines us as having made a list of all possible partitions, the ones shown above and also all 7 other possible partitions, which correspond to branches that are not found in this tree. These are assigned branch lengths of 0. For two trees, we imagine constructing these lists, and then summing the squared differences between the branch lengths. Thus if both trees have branches {A, D | B, C, E}, the sum contains the square of the difference between the branch lengths. If one tree has the branch and the other doesn't, it contains the square of the difference between the branch length and zero (in other words, the square of that branch length). If both trees do not have a particular branch, nothing is added to the sum because the difference is then between 0 and 0.
The Branch Score Distance takes this sum of squared differences and computes its square root. Note that it has some desirable properties. When small branches differ in tree topology, it is not very big. When branches are both present but differ in length, it is affected.
The Symmetric Difference is simply a count of how many partitions there are, among the two trees, that are on one tree and not on the other. In the example above there are two partitions, {A, C | B, D, E} and {A, D | B, C, E}, each of which is present on only one of the two trees. The Symmetric Difference between the two trees is therefore 2. When the two trees are fully resolved bifurcating trees, their symmetric distance must be an even number; it can range from 0 to twice the number of internal branches, which for n species is 4n-6.
Note the relationship between the two distances. If all trees have all their branches have length 1.0, the Branch Score Distance is the square of the Symmetric Difference, as each branch that is present in one but not in the other results in 1.0 being added to the sum of squared differences.
We have assumed that nothing is lost if the trees are treated as unrooted trees. It is easy to define a counterpart to the Branch Score Distance and one to the Symmetric Difference for these rooted trees. Each branch then defines a set of species, namely the clade defined by that branch. Thus if the first of the two trees above were considered as a rooted tree it would define the three clades {A, C}, {B, D, E}, and {B, E}. The Branch Score Distance is computed from the branch lengths for all possible sets of species, with 0 put for each set that does not occur on that tree. The table above will be nearly the same, but with two entries instead of one for the sets on either side of the root, {A C D} and {B E}. The Symmetric Difference between two rooted trees is simply the count of the number of clades that are defined by one but not by the other. For the second tree the clades would be {A, D}, {B, C, E}, and {B, E}. The Symmetric Difference between thee two rooted trees would then be 4.
Although the examples we have discussed have involved fully bifurcating trees, the input trees can have multifurcations. This does not cause any complication for the Branch Score Distance. For the Symmetric Difference, it can lead to distances that are odd numbers.
However, note one strong restriction. The trees should all have the same list of species. If you use one set of species in the first two trees, and another in the second two, and choose distances for adjacent pairs, the distances will be incorrect and will depend on the order of these pairs in the input tree file, in odd ways.
% ftreedistpair -style s Distances between two sets of trees Phylip tree file: treedist.dat Second phylip tree file: treedist.dat Phylip treedist program output file [treedist.ftreedistpair]: read_groups 9b1cdc0 Done. |
Go to the input files for this example
Go to the output files for this example
Standard (Mandatory) qualifiers:
[-intreefile] tree Phylip tree file
[-bintreefile] tree Second phylip tree file
[-outfile] outfile [*.ftreedistpair] Phylip treedist program
output file
Additional (Optional) qualifiers:
-dtype menu [b] Distance type (Values: s (Symmetric
difference); b (Branch score distance))
-pairing menu [l] Tree pairing method (Values: c
(Distances between corresponding pairs each
tree file); l (Distances between all
possible pairs in each tree file))
-style menu [v] Distances output option (Values: f
(Full_matrix); v (One pair per line,
verbose); s (One pair per line, sparese))
-noroot boolean [N] Trees to be treated as rooted
-outgrno integer [0] Species number to use as outgroup
(Integer 0 or more)
-progress boolean [N] Print indications of progress of run
Advanced (Unprompted) qualifiers: (none)
Associated qualifiers:
"-outfile" associated qualifiers
-odirectory3 string Output directory
General qualifiers:
-auto boolean Turn off prompts
-stdout boolean Write first file to standard output
-filter boolean Read first file from standard input, write
first file to standard output
-options boolean Prompt for standard and additional values
-debug boolean Write debug output to program.dbg
-verbose boolean Report some/full command line options
-help boolean Report command line options. More
information on associated and general
qualifiers can be found with -help -verbose
-warning boolean Report warnings
-error boolean Report errors
-fatal boolean Report fatal errors
-die boolean Report dying program messages
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| Standard (Mandatory) qualifiers | Allowed values | Default | |||||||
|---|---|---|---|---|---|---|---|---|---|
| [-intreefile] (Parameter 1) |
Phylip tree file | Phylogenetic tree | |||||||
| [-bintreefile] (Parameter 2) |
Second phylip tree file | Phylogenetic tree | |||||||
| [-outfile] (Parameter 3) |
Phylip treedist program output file | Output file | <*>.ftreedistpair | ||||||
| Additional (Optional) qualifiers | Allowed values | Default | |||||||
| -dtype | Distance type |
|
b | ||||||
| -pairing | Tree pairing method |
|
l | ||||||
| -style | Distances output option |
|
v | ||||||
| -noroot | Trees to be treated as rooted | Boolean value Yes/No | No | ||||||
| -outgrno | Species number to use as outgroup | Integer 0 or more | 0 | ||||||
| -progress | Print indications of progress of run | Boolean value Yes/No | No | ||||||
| Advanced (Unprompted) qualifiers | Allowed values | Default | |||||||
| (none) | |||||||||
(A:0.1,(B:0.1,(H:0.1,(D:0.1,(J:0.1,(((G:0.1,E:0.1):0.1,(F:0.1,I:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(D:0.1,((J:0.1,H:0.1):0.1,(((G:0.1,E:0.1):0.1, (F:0.1,I:0.1):0.1):0.1,C:0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(D:0.1,(H:0.1,(J:0.1,(((G:0.1,E:0.1):0.1,(F:0.1,I:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,(G:0.1,((F:0.1,I:0.1):0.1,((J:0.1,(H:0.1,D:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,(G:0.1,((F:0.1,I:0.1):0.1,(((J:0.1,H:0.1):0.1,D:0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,((F:0.1,I:0.1):0.1,(G:0.1,((J:0.1,(H:0.1,D:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,((F:0.1,I:0.1):0.1,(G:0.1,(((J:0.1,H:0.1):0.1,D:0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,((G:0.1,(F:0.1,I:0.1):0.1):0.1,((J:0.1,(H:0.1, D:0.1):0.1):0.1,C:0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,((G:0.1,(F:0.1,I:0.1):0.1):0.1,(((J:0.1,H:0.1):0.1, D:0.1):0.1,C:0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,(G:0.1,((F:0.1,I:0.1):0.1,((J:0.1,(H:0.1,D:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(D:0.1,(H:0.1,(J:0.1,(((G:0.1,E:0.1):0.1,(F:0.1,I:0.1):0.1):0.1, C:0.1):0.1):0.1):0.1):0.1):0.1); (A:0.1,(B:0.1,(E:0.1,((G:0.1,(F:0.1,I:0.1):0.1):0.1,((J:0.1,(H:0.1, D:0.1):0.1):0.1,C:0.1):0.1):0.1):0.1):0.1); |
The Full matrix (choice F) is a table showing all distances. It is written onto the output file. The table is presented as groups of 10 columns. Here is the Full matrix for the 12 trees in the input tree file which is given as an example at the end of this page.
Tree distance program, version 3.6
Symmetric differences between all pairs of trees in tree file:
1 2 3 4 5 6 7 8 9 10
\------------------------------------------------------------
1 | 0 4 2 10 10 10 10 10 10 10
2 | 4 0 2 10 8 10 8 10 8 10
3 | 2 2 0 10 10 10 10 10 10 10
4 | 10 10 10 0 2 2 4 2 4 0
5 | 10 8 10 2 0 4 2 4 2 2
6 | 10 10 10 2 4 0 2 2 4 2
7 | 10 8 10 4 2 2 0 4 2 4
8 | 10 10 10 2 4 2 4 0 2 2
9 | 10 8 10 4 2 4 2 2 0 4
10 | 10 10 10 0 2 2 4 2 4 0
11 | 2 2 0 10 10 10 10 10 10 10
12 | 10 10 10 2 4 2 4 0 2 2
11 12
\------------
1 | 2 10
2 | 2 10
3 | 0 10
4 | 10 2
5 | 10 4
6 | 10 2
7 | 10 4
8 | 10 0
9 | 10 2
10 | 10 2
11 | 0 10
12 | 10 0
The Full matrix is only available for analyses P and L (not for A or C).
Option V (Verbose) writes one distance per line. The Verbose output is the default. Here it is for the example data set given below:
Tree distance program, version 3.6 Symmetric differences between adjacent pairs of trees: Trees 1 and 2: 4 Trees 3 and 4: 10 Trees 5 and 6: 4 Trees 7 and 8: 4 Trees 9 and 10: 4 Trees 11 and 12: 10
Option S (Sparse or terse) is similar except that all that is given on each line are the numbers of the two trees and the distance, separated by blanks. This may be a convenient format if you want to write a program to read these numbers in, and you want to spare yourself the effort of having the program wade through the words on each line in the Verbose output. The first four lines of the Sparse output are titles that your program would want to skip past. Here is the Sparse output for the example trees.
1 2 4 3 4 10 5 6 4 7 8 4 9 10 4 11 12 10
1 13 0.000000e+00 1 14 2.000000e-01 1 15 1.414214e-01 1 16 3.162278e-01 1 17 3.162278e-01 1 18 3.162278e-01 1 19 3.162278e-01 1 20 3.162278e-01 1 21 3.162278e-01 1 22 3.162278e-01 1 23 1.414214e-01 1 24 3.162278e-01 2 13 2.000000e-01 2 14 0.000000e+00 2 15 1.414214e-01 2 16 3.162278e-01 2 17 2.828427e-01 2 18 3.162278e-01 2 19 2.828427e-01 2 20 3.162278e-01 2 21 2.828427e-01 2 22 3.162278e-01 2 23 1.414214e-01 2 24 3.162278e-01 3 13 1.414214e-01 3 14 1.414214e-01 3 15 0.000000e+00 3 16 3.162278e-01 3 17 3.162278e-01 3 18 3.162278e-01 3 19 3.162278e-01 3 20 3.162278e-01 3 21 3.162278e-01 3 22 3.162278e-01 3 23 0.000000e+00 3 24 3.162278e-01 4 13 3.162278e-01 4 14 3.162278e-01 4 15 3.162278e-01 4 16 0.000000e+00 4 17 1.414214e-01 4 18 1.414214e-01 4 19 2.000000e-01 4 20 1.414214e-01 4 21 2.000000e-01 4 22 0.000000e+00 4 23 3.162278e-01 4 24 1.414214e-01 5 13 3.162278e-01 5 14 2.828427e-01 [Part of this file has been deleted for brevity] 20 10 1.414214e-01 20 11 3.162278e-01 20 12 0.000000e+00 21 1 3.162278e-01 21 2 2.828427e-01 21 3 3.162278e-01 21 4 2.000000e-01 21 5 1.414214e-01 21 6 2.000000e-01 21 7 1.414214e-01 21 8 1.414214e-01 21 9 0.000000e+00 21 10 2.000000e-01 21 11 3.162278e-01 21 12 1.414214e-01 22 1 3.162278e-01 22 2 3.162278e-01 22 3 3.162278e-01 22 4 0.000000e+00 22 5 1.414214e-01 22 6 1.414214e-01 22 7 2.000000e-01 22 8 1.414214e-01 22 9 2.000000e-01 22 10 0.000000e+00 22 11 3.162278e-01 22 12 1.414214e-01 23 1 1.414214e-01 23 2 1.414214e-01 23 3 0.000000e+00 23 4 3.162278e-01 23 5 3.162278e-01 23 6 3.162278e-01 23 7 3.162278e-01 23 8 3.162278e-01 23 9 3.162278e-01 23 10 3.162278e-01 23 11 0.000000e+00 23 12 3.162278e-01 24 1 3.162278e-01 24 2 3.162278e-01 24 3 3.162278e-01 24 4 1.414214e-01 24 5 2.000000e-01 24 6 1.414214e-01 24 7 2.000000e-01 24 8 0.000000e+00 24 9 1.414214e-01 24 10 1.414214e-01 24 11 3.162278e-01 24 12 0.000000e+00 |
| Program name | Description |
|---|---|
| econsense | Majority-rule and strict consensus tree |
| fconsense | Majority-rule and strict consensus tree |
| ftreedist | Distances between trees |
Although we take every care to ensure that the results of the EMBOSS version are identical to those from the original package, we recommend that you check your inputs give the same results in both versions before publication.
Please report all bugs in the EMBOSS version to the EMBOSS bug team, not to the original author.
Converted (August 2004) to an EMBASSY program by the EMBOSS team.